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|Year : 2000 | Volume
| Issue : 5 | Page : 318--320
Role of nitric oxide in central regulation of humoral immune response in rats
Roy Sunita1, Roy Goutam2, SC Mishra3, V Raviprakash4
Objective: To investigate the role of nitric oxide (NO) in central regulation of immune response in rats.
Methods: The investigation was carried out using sheep red blood cells (SRBC)-immunized rats. The animals were administered NO modulators intracerebroventricularly ( icv), both prior to, and following immunization. Blood collected postimmunization was analyzed for humoral immune response by haemagglutination test.
Results: Centrally administered NO stimulators (L-arginine and SIN-1) were found to have immunopotentiating effect whereas, L- NAME (NOS inhibitor) and methylene blue (guanylyl cyclase inhibitor) did not produce any change in humoral immune response.
Conclusion: L- arginine (NO precursor) and SIN-1 (NO donor) when administered icv produced an increase in the anti-SRBC antibody titre, while L-NAME and methylene blue (NO inhibitors) did not alter this humoral immune response.
|How to cite this article:|
Sunita R, Goutam R, Mishra S C, Raviprakash V. Role of nitric oxide in central regulation of humoral immune response in rats.Indian J Pharmacol 2000;32:318-320
|How to cite this URL:|
Sunita R, Goutam R, Mishra S C, Raviprakash V. Role of nitric oxide in central regulation of humoral immune response in rats. Indian J Pharmacol [serial online] 2000 [cited 2023 Jun 9 ];32:318-320
Available from: https://www.ijp-online.com/article.asp?issn=0253-7613;year=2000;volume=32;issue=5;spage=318;epage=320;aulast=Sunita;type=0