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Year : 2000  |  Volume : 32  |  Issue : 1  |  Page : 31--33

Facilitation of behavioural depression by antiepileptic drugs

SK Srivastava 
 

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S K Srivastava


Objective: To investigate the effect of certain antiepileptic drugs on behavioural depression in mice. Methods: The study was conducted in Swiss albino mice of either sex weighing 25-35 g in behavioural despair test. The mice were acutely treated with carbamazepine (20 and 40 mg/kg, p.o.) sodium valproate (100 and 200 mg/kg, p.o.) and gabapentin (3, 10 and 30 mg/kg, i.p.) and effect of these drugs were observed 60 min after the drug treatment. In each set up of experiment duration of immobility in last 5 min (during 6 min session) was recorded and analysed to find out the effect on depression. Results: Carbamazepine, sodium valproate and gabapentin in higher doses significantly and dose dependently increased the duration of immobility in behavioural despair test. Conclusion: Carbamazepine, sodium valproate and gabapentine facilitates depression in the above animal model.


How to cite this article:
Srivastava S K. Facilitation of behavioural depression by antiepileptic drugs.Indian J Pharmacol 2000;32:31-33


How to cite this URL:
Srivastava S K. Facilitation of behavioural depression by antiepileptic drugs. Indian J Pharmacol [serial online] 2000 [cited 2022 Jan 22 ];32:31-33
Available from: https://www.ijp-online.com/article.asp?issn=0253-7613;year=2000;volume=32;issue=1;spage=31;epage=33;aulast=Srivastava;type=0