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Year : 2000  |  Volume : 32  |  Issue : 1  |  Page : 25--27

Study on the action of captopril: A sulfhydryl donor on rodent ulcer

Dau Harminder1, CK Chauhan2, S Shahani3 
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Correspondence Address:
Dau Harminder


Objective: To evaluate ulcero-protective property of captopril-a sulfhydryl donor in rats. Methods: The study was done in rats by inducing gastric ulcer by oxyphenbutazone, 0.6 M hydrochloric acid and restrain stress and the effect of different doses of captopril alone or/and omeprazole was studied. Effect of paracetamol-a depleter of glutathione of stomach was observed over captopril and/or omeprazole. Results: Captopril produced dose dependent protection against experimentally induced gastric ulcer in rats. Its ulcero-protective effect was enhanced by omeprazole. Paracetamol reduced the protection offered by both the agents alone and in combination. Conclusion: Captopril produced dose dependent protection against experimentally induced gastric ulcer. Its protective effect was enhanced by omeprazole and reduced by paracetamol suggesting a possible involvement of sulfhydryl group of captopril in ulcer protection.


How to cite this article:
Harminder D, Chauhan C K, Shahani S. Study on the action of captopril: A sulfhydryl donor on rodent ulcer.Indian J Pharmacol 2000;32:25-27


How to cite this URL:
Harminder D, Chauhan C K, Shahani S. Study on the action of captopril: A sulfhydryl donor on rodent ulcer. Indian J Pharmacol [serial online] 2000 [cited 2022 Jan 20 ];32:25-27
Available from: https://www.ijp-online.com/article.asp?issn=0253-7613;year=2000;volume=32;issue=1;spage=25;epage=27;aulast=Harminder;type=0