RESEARCH PAPER |
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| Year : 1999 | Volume
: 31
| Issue : 5 | Page : 340--344 |
Calcium entry into myometrial cells is inhibited by tamoxifen and 4-monohydroxytamoxifen
MJ Wilkinson1, Anthony Lipton2
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2
Correspondence Address:
M J Wilkinson
Objectives: To investigate whether tamoxifen, oestradiol and 4-monohydroxytamoxifen inhibit entry of calcium into rat myometrium.
Methods: Pieces of myometrium were incubated in media containing tamoxifen, oestradiol or 4- monohydroxytamoxifen, in the presence or absence of known myometrial spasmogens (80 mM KCl or 1.28 nM oxytocin). Following incubation the tissues were dried and the uptake of 45 Ca 2+ measured.
Results: OH-tamoxifen inhibited the entry of 45 Ca 2+ entry in both normal (5.9 mM KCl) and high potassium (80 mM KCl) media while tamoxifen and oestradiol inhibited 45 Ca 2+ entry only in high potassium media. 20 (M 17(-oestradiol also inhibited calcium influx in oxytocin (1.28 nM) stimulated tissues, no inhibition was observed with tamoxifen.
Conclusions: Tamoxifen and its metabolite, 4-monohydroxytamoxifen (OH-tamoxifen) may obstruct ion-channel, but not receptor, mediated entry of calcium into rat myometrium.
How to cite this article:
Wilkinson M J, Lipton A. Calcium entry into myometrial cells is inhibited by tamoxifen and 4-monohydroxytamoxifen.Indian J Pharmacol 1999;31:340-344
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How to cite this URL:
Wilkinson M J, Lipton A. Calcium entry into myometrial cells is inhibited by tamoxifen and 4-monohydroxytamoxifen. Indian J Pharmacol [serial online] 1999 [cited 2023 Jun 3 ];31:340-344
Available from: https://www.ijp-online.com/article.asp?issn=0253-7613;year=1999;volume=31;issue=5;spage=340;epage=344;aulast=Wilkinson;type=0 |
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