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Year : 1999  |  Volume : 31  |  Issue : 2  |  Page : 96--103

Antiretroviral drugs in HIV infection

Vajpayee Madhu1, Dar Lalit2 

Correspondence Address:
Vajpayee Madhu

Antiretroviral drugs directed at various targets in the replication cycle of HIV are now in clinical use. The earliest drugs available were the nucleoside analogue reverse transcriptase (RT) inhibitors. Subsequently non-nucleoside RT inhibitors were also introduced into clinical use. The newly developed HIV protease inhibitors have shown excellent efficacy, leading to optimistic attempts at «DQ»virus eradication«DQ». The trend in HIV antiretroviral therapy has shifted in recent years from monotherapy to combination therapy with even 3 drugs used simultaneously, and from treatment late in disease to early in infection. These approaches are based on the replication characteristics of the virus. A large number of clinical trials have been carried out and are ongoing for the evaluation of the various antiretroviral drugs in different treatment regimens. This review presents information on the antiretroviral drugs currently available for clinical use against HIV, along with the rationale and evolution of the strategies of anti-HIV therapy.

How to cite this article:
Madhu V, Lalit D. Antiretroviral drugs in HIV infection.Indian J Pharmacol 1999;31:96-103

How to cite this URL:
Madhu V, Lalit D. Antiretroviral drugs in HIV infection. Indian J Pharmacol [serial online] 1999 [cited 2021 Nov 30 ];31:96-103
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