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|Year : 1999 | Volume
| Issue : 2 | Page : 138--141
Investigations into the anti-diabetic activity of Azadirachta indica
Bajaj Sonia1, BP Srinivasan2
Objective: To investigate the anti-diabetic activity of Azadirachta Indica using IDDM and NIDDM animal models .
Methods: Streptozotocin induced models of IDDM (65 mg/kg, iv) as well as NIDDM model (90 mg/kg, i.p in neonates) were given neem leaf extract (NLE, 1 g/kg, po) for 6 weeks and their anti-diabetic activity was assessed.
Result: The treatment with insulin, aqueous NLE, aqueous NLE with insulin and insulin with aminoguanidine showed a fall in blood glucose levels of 80, 45.4, 38.02 and 77-65% whereas in NIDDM model, a fall of 53.95 and 60.50% were observed with glibenclamide and NLE.
Conclusion: Aqueous extract of NLE has a good therapeutic potential as anti-hyperglycaemic agent in IDDM and NIDDM.
|How to cite this article:|
Sonia B, Srinivasan B P. Investigations into the anti-diabetic activity of Azadirachta indica.Indian J Pharmacol 1999;31:138-141
|How to cite this URL:|
Sonia B, Srinivasan B P. Investigations into the anti-diabetic activity of Azadirachta indica. Indian J Pharmacol [serial online] 1999 [cited 2021 Nov 27 ];31:138-141
Available from: https://www.ijp-online.com/article.asp?issn=0253-7613;year=1999;volume=31;issue=2;spage=138;epage=141;aulast=Sonia;type=0