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|Year : 1999 | Volume
| Issue : 2 | Page : 133--137
Antiasthmatic and antianaphylactic effect of E-721B, a herbal formulation
SK Mitra1, S Gopumadhavan2, MV Venkataranganna3, SD Anturlikar4
Objective: To evaluate the antiasthmatic and antianaphylactic activity of E-721B in various experimental models.
Methods: The antiasthmatic and antianaphylactic activity of E-721B was studied on the active and passive anaphylaxis in rats, acetyl choline-induced bronchospasm in guinea pigs, anaphylactic shock-induced bronchospasm in guinea pigs and rats and on degranulation of mast cells by Compound 48/80.
Results: Treatment with E-721B showed a dose dependent (at 50, 100, 250 and 500 mg/kg p.o.) beneficial effect on degranulation rate of actively and passively sensitized mesenteric mast cells of albino rats when challenged with antigen (horse serum). E-721B treatment for 7 days resulted in significant protection against acetylcholine aerosol-induced bronchospasm in guinea pigs. E-721B treatment for 10 and 14 days, in guinea pigs and rats respectively, offered marked protection against anaphylactic shock-induced bronchospasm. E 721B treatment also protected the mast cell disruption induced by Compound 48/80.
Conclusion: Antiasthmatic and antianaphylactic activity of E-721B may be possibly due to the membrane stabilising potential, suppression of antibody production and inhibition of antigen induced histamine release.
S K Mitra
|How to cite this article:|
Mitra S K, Gopumadhavan S, Venkataranganna M V, Anturlikar S D. Antiasthmatic and antianaphylactic effect of E-721B, a herbal formulation.Indian J Pharmacol 1999;31:133-137
|How to cite this URL:|
Mitra S K, Gopumadhavan S, Venkataranganna M V, Anturlikar S D. Antiasthmatic and antianaphylactic effect of E-721B, a herbal formulation. Indian J Pharmacol [serial online] 1999 [cited 2021 Sep 23 ];31:133-137
Available from: https://www.ijp-online.com/article.asp?issn=0253-7613;year=1999;volume=31;issue=2;spage=133;epage=137;aulast=Mitra;type=0