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Year : 1998  |  Volume : 30  |  Issue : 5  |  Page : 329--333

Proconvulsant effect of buspirone and its modulation by a2-adrenoceptor agonist in mice

Vohora Divya1, KK Pillai2 
1 
2 

Correspondence Address:
Vohora Divya


Objectives: To study (a) the effect of buspirone on chemically-induced seizures in mice and (b) the possible receptor mechanisms involved. Methods: Picrotoxin 8 mg/kg ip was used for inducing seizures in mice. The onset and duration of convulsions and recovery/ death were observed. Animals were also observed for different stages of convulsions and a severity score was assigned to them. Results: Buspirone (20 mg/kg po) potentiated PTX-induced convulsions and reversed the anticonvulsant effect of diazepam. Clonidine pretreatment protected against the pro-convulsive effects of buspirone. Mianserin exhibited an effect similar to that of buspirone. Conclusion: Buspirone exhibited pro-convulsive action on seizures induced with PTX in mice. The study suggests a role of central ((-adrenoceptor in such effects.


How to cite this article:
Divya V, Pillai K K. Proconvulsant effect of buspirone and its modulation by a2-adrenoceptor agonist in mice.Indian J Pharmacol 1998;30:329-333


How to cite this URL:
Divya V, Pillai K K. Proconvulsant effect of buspirone and its modulation by a2-adrenoceptor agonist in mice. Indian J Pharmacol [serial online] 1998 [cited 2021 Oct 28 ];30:329-333
Available from: https://www.ijp-online.com/article.asp?issn=0253-7613;year=1998;volume=30;issue=5;spage=329;epage=333;aulast=Divya;type=0