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Year : 1998  |  Volume : 30  |  Issue : 4  |  Page : 254--256

Effect of trikatu (PIPERINE) on the pharmacokinetic profile of isoniazid in rabbits

RS Karan1, VK Bhargava2, SK Garg3 
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Correspondence Address:
R S Karan


Objective: To see the effect of Trikatu (piperine) on the bioavailability and pharmacokinetics of isoniazid in rabbits. Methods: In a crossover study, ten rabbits were administered either single dose (orally) of isoniazid (14 mg/kg) alone or in combination with Trikatu [piperine (10mg/kg)] Blood samples were collected at 0,0.5,1 ,1.5,2, 4,6,9 and 12 hours after drug administration and assayed for isoniazid by fluorimetric technique. A washout period of 7 days was allowed between the two treatments. Results : Coadministratfon of Trikatu (piperine) significantly reduced the Cmax (5.48 0.75 g/ml vs 8.42 0.85 g/ml; P < 0.05] and AUCo-( [15.04 3.64 g/ml. hr vs 24.76(4.03 g/ml. hr; P< 0.05] of isoniazid. Condusion: Trikatu (piperine) reduces the bioavailability of isoniazid in rabbits.


How to cite this article:
Karan R S, Bhargava V K, Garg S K. Effect of trikatu (PIPERINE) on the pharmacokinetic profile of isoniazid in rabbits.Indian J Pharmacol 1998;30:254-256


How to cite this URL:
Karan R S, Bhargava V K, Garg S K. Effect of trikatu (PIPERINE) on the pharmacokinetic profile of isoniazid in rabbits. Indian J Pharmacol [serial online] 1998 [cited 2022 Jul 4 ];30:254-256
Available from: https://www.ijp-online.com/article.asp?issn=0253-7613;year=1998;volume=30;issue=4;spage=254;epage=256;aulast=Karan;type=0