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|Year : 1998 | Volume
| Issue : 3 | Page : 191--194
Comparative pharmacokinetic evaluation of compressed rectal suppositories of diltiazem hydrochloride in rabbits
Rao P Rama1, Kumar D Vijay2, PV Diwan3
Objectives: To evaluate the bioavailability of rectally administered diltiazem hydrochloride in rabbits
Methods: Compressed rectal suppositories of diltiazem hydrochloride were formulated employing polyethylene glycol 4000 as base. The bioavailability of diltiazem hydrochloride from rectal suppositories was compared with that of oral administration of same dose of the drug. This study was carried out in a randomized cross over design and various pharmacokinetic parameters were calculated.
Results: The maximum serum concentration (Cmax) and area under the curve (AUC0-() were significantly (p<0.05) higher in the case of rectal administration compared to oral administration. However, there was no significant difference in time for peak serum concentration (tmax) and elimination half-life (t1/2) for both rectal and oral route.
Conclusions: The relative bioavailability of diltiazem hydrochloride was about 75% greater after rectal administration compared to oral route.This may be due to the avoidance of biotransformation of diltiazem by liver, intestine and lungs.
Rao P Rama
|How to cite this article:|
Rama RP, Vijay KD, Diwan P V. Comparative pharmacokinetic evaluation of compressed rectal suppositories of diltiazem hydrochloride in rabbits.Indian J Pharmacol 1998;30:191-194
|How to cite this URL:|
Rama RP, Vijay KD, Diwan P V. Comparative pharmacokinetic evaluation of compressed rectal suppositories of diltiazem hydrochloride in rabbits. Indian J Pharmacol [serial online] 1998 [cited 2021 Dec 7 ];30:191-194
Available from: https://www.ijp-online.com/article.asp?issn=0253-7613;year=1998;volume=30;issue=3;spage=191;epage=194;aulast=Rama;type=0