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|Year : 1998 | Volume
| Issue : 3 | Page : 181--185
Effect of Lawsonia inermis on memory and behaviour mediated via monoamine neurotransmitters
MR Iyer1, SC Pal2, VS Kasture3, SB Kasture4
Objective: To investigate the effect of acetone soluble fraction of petroleum ether extract of Lawsonia inermis leaves on memory, anxiety and behaviour mediated via monoamine neurotransmitters.
Methods: The effect of acetone soluble fraction of pet. ether extract of Lawsonia inermis on memory was assessed using elevated plus maze and passive shock avoidance paradigms.The effects on clonidine induced hypothermia.lithium induced head twitches and haloperidol induced catalepsy were observed to study the effect on noradrenaline, serotonin and dopamine mediated behaviour respectively
Results: The acetone fraction of pet.ether extract of L. inermis exhibited prominent nootropic activity, potenttated clonidine induoed hypothermia and decreased lithium induced head twitches. However, the haloperidol induced catalepsy was not modified.
Conclusion: The acetone soluble fraction of pet. ether extract exhibited prominent nootropic activity.The fraction modified 5-HT and NA mediated behaviour. It is concluded that the leaves of L. inermis possess a potential for exploring a nootropic principle.
M R Iyer
|How to cite this article:|
Iyer M R, Pal S C, Kasture V S, Kasture S B. Effect of Lawsonia inermis on memory and behaviour mediated via monoamine neurotransmitters.Indian J Pharmacol 1998;30:181-185
|How to cite this URL:|
Iyer M R, Pal S C, Kasture V S, Kasture S B. Effect of Lawsonia inermis on memory and behaviour mediated via monoamine neurotransmitters. Indian J Pharmacol [serial online] 1998 [cited 2023 Sep 27 ];30:181-185
Available from: https://www.ijp-online.com/article.asp?issn=0253-7613;year=1998;volume=30;issue=3;spage=181;epage=185;aulast=Iyer;type=0