Indian Journal of Pharmacology Home 

RESEARCH PAPER
[Download PDF]
Year : 1998  |  Volume : 30  |  Issue : 2  |  Page : 94--96

An experimental and clinical evaluation of immunomodulating potential of ascorbic acid

KU Ansari1, N Kastury2, SL Tewarson3, S Singh4, RC Pandey5 
1 
2 
3 
4 
5 

Correspondence Address:
K U Ansari


Objectives: To find the effects of ascorbic acid on immune system in rabbits and human volunteers. Methods: In humans, humoral immunity was measured by immunoglobulin estimation (IgG, IgM, IgA) using tripantigen plates and cell mediated immunity by total lymphocyte count and T-cell count. In rabbits, widal agglutination test using typhoid-H antigen and Dinitro chlorobenzene (DNCB) and tuberculin skin sensitivity tests were performed as measurement of humoral and cell-mediated immunity, respectively. Result: Administration of ascorbic acid 500 mg thrice daily orally for 21 days increased serum immunoglobulin in human subjects. In rabbits, ascorbic acid administration in the dose of 200 mg/kg/day orally for 21 days caused a rise in antibody titre. No effect on cell mediated immunity was found in human as well as animal models. Conclusion: Ascorbic acid appears to stimulate humoral immunity through increased antibody synthesis particularly IgG, IgA and IgM types and also by activating the macrophages.


How to cite this article:
Ansari K U, Kastury N, Tewarson S L, Singh S, Pandey R C. An experimental and clinical evaluation of immunomodulating potential of ascorbic acid.Indian J Pharmacol 1998;30:94-96


How to cite this URL:
Ansari K U, Kastury N, Tewarson S L, Singh S, Pandey R C. An experimental and clinical evaluation of immunomodulating potential of ascorbic acid. Indian J Pharmacol [serial online] 1998 [cited 2022 Jun 30 ];30:94-96
Available from: https://www.ijp-online.com/article.asp?issn=0253-7613;year=1998;volume=30;issue=2;spage=94;epage=96;aulast=Ansari;type=0