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Year : 1997  |  Volume : 29  |  Issue : 5  |  Page : 366--372

Central and uterotonic effects of cycleanine

C Wambebe1, K Gamaniel2, PA Akah3, SD Kapu4, A Samson5, AT Orisadipe6, JI Okogun7 
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Correspondence Address:
C Wambebe


Cycleanine, an alkaloidal extractive from the root bark of Synclisia scabridav, was screened for some peripheral and central effects in addition to acute toxicological investigation. The intraperitoneal LD50 in mice was established as 1010.5 mg/kg. In vivo studies using mice revealed that cycleanine significantly reduced spontaneous motor activity (SMA) in a dose related manner. There was synchronization of EEG and activation of EMG. In vitro studies using isolated rat uterus showed that cycleanine evoked concentration dependent contractions that were resistant to atropine but blocked by salbutamol. These results help to explain the rationale for the folkloric use of the plant in various CNS and peripheral disorders, and also implicate cycleanine as the putative active component.


How to cite this article:
Wambebe C, Gamaniel K, Akah P A, Kapu S D, Samson A, Orisadipe A T, Okogun J I. Central and uterotonic effects of cycleanine.Indian J Pharmacol 1997;29:366-372


How to cite this URL:
Wambebe C, Gamaniel K, Akah P A, Kapu S D, Samson A, Orisadipe A T, Okogun J I. Central and uterotonic effects of cycleanine. Indian J Pharmacol [serial online] 1997 [cited 2022 Aug 10 ];29:366-372
Available from: https://www.ijp-online.com/article.asp?issn=0253-7613;year=1997;volume=29;issue=5;spage=366;epage=372;aulast=Wambebe;type=0