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Year : 1997  |  Volume : 29  |  Issue : 5  |  Page : 318--321

The effect of Panax ginseng and diazepam on brain and hypothalamic 5-hydroxytryptamine during stress

TK Sur1, D Bhattacharyya2 
1 
2 

Correspondence Address:
T K Sur


Objective: To see the efect of anti-stress agents like Panax ginseng and diazepam on stress-induced elevation of 5-hydroxytryptamine (5-HT) in brain and hypothalamus of rats. Methods: 5-HT was estimated in brain and hypothalamus of rats by spectrophotofluorometry with simultaneous fluorimetric estimation of corticosterone as an index of activation of hypothalamo-hypophyseal- adrenal axis. Results: Panax ginseng and diazepam both per se did not modify brain and hypothalamic 5-HT in unstressed rats. But both of them attenuated stress-induced elevation of brin and hypothalamic 5-HT. Conclusion: Mediation of 5-HT in anti-stress effect of Panax ginseng and diazepam can not be conjectured, as they may have a non specific anti-stress effect.


How to cite this article:
Sur T K, Bhattacharyya D. The effect of Panax ginseng and diazepam on brain and hypothalamic 5-hydroxytryptamine during stress.Indian J Pharmacol 1997;29:318-321


How to cite this URL:
Sur T K, Bhattacharyya D. The effect of Panax ginseng and diazepam on brain and hypothalamic 5-hydroxytryptamine during stress. Indian J Pharmacol [serial online] 1997 [cited 2021 Sep 20 ];29:318-321
Available from: https://www.ijp-online.com/article.asp?issn=0253-7613;year=1997;volume=29;issue=5;spage=318;epage=321;aulast=Sur;type=0