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|Year : 1997 | Volume
| Issue : 5 | Page : 310--313
Effect of metoprolol and prazosin alone and in combination in reperfusion induced arrhythmias in intact rabbits
D Sharma1, P Pandhi2
Objective: To investigate the effect of metoprolol (cardioselective beta blocker), prazosin (alpha blocker) alone and in combination on reperfusion induced arrhythmias in intact rabbit hearts.
Methods: Newzealand white rabbits of either sex weighing 1.5 to 2 kg were used. The coronary artery was ligated for 30 minutes and then reperfusion was carried out for 60 minutes. Metoprolol alone (0.5 mg, 0.75 mg and 1mg/kg B.wt.), prazosin alone (0.25 mg, 0.5 mg and 1mg/kg B.wt.) and combination of lowest dose of metoprolol (0.5 mg/kg) and prazosin (0.25 mgkg) was administered intravenously at the time of reperfusion in different groups of animals. Electrocardiogram was monitored every 5 minutes using limb lead II throughout the experiment. Incidence and severity of arrhythmias were analysed from ECG recordings.
Results: Metoprolol in all doses produced slight bradycardia and percent protection against arrhythmias was 0 to 16.6% with different doses.Percent protection produced by prazosin was 33.3 to 66.6%. When metoprolol (lowest dose) was used in combination with prazosin (lowest dose) there was no change in heart rate and percent protection against arrhythmias was 83.3%.
Conclusion: Combination of a cardioselective beta blocker (metoprolol) and an alpha blocker (prazosin) has produced potentiation of effect in protecting the heart against reperfusion induced arrhythmias in intact rabbit heart.
|How to cite this article:|
Sharma D, Pandhi P. Effect of metoprolol and prazosin alone and in combination in reperfusion induced arrhythmias in intact rabbits.Indian J Pharmacol 1997;29:310-313
|How to cite this URL:|
Sharma D, Pandhi P. Effect of metoprolol and prazosin alone and in combination in reperfusion induced arrhythmias in intact rabbits. Indian J Pharmacol [serial online] 1997 [cited 2021 Sep 19 ];29:310-313
Available from: https://www.ijp-online.com/article.asp?issn=0253-7613;year=1997;volume=29;issue=5;spage=310;epage=313;aulast=Sharma;type=0