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Year : 1997  |  Volume : 29  |  Issue : 5  |  Page : 310--313

Effect of metoprolol and prazosin alone and in combination in reperfusion induced arrhythmias in intact rabbits

D Sharma1, P Pandhi2 
1 
2 

Correspondence Address:
D Sharma


Objective: To investigate the effect of metoprolol (cardioselective beta blocker), prazosin (alpha blocker) alone and in combination on reperfusion induced arrhythmias in intact rabbit hearts. Methods: Newzealand white rabbits of either sex weighing 1.5 to 2 kg were used. The coronary artery was ligated for 30 minutes and then reperfusion was carried out for 60 minutes. Metoprolol alone (0.5 mg, 0.75 mg and 1mg/kg B.wt.), prazosin alone (0.25 mg, 0.5 mg and 1mg/kg B.wt.) and combination of lowest dose of metoprolol (0.5 mg/kg) and prazosin (0.25 mgkg) was administered intravenously at the time of reperfusion in different groups of animals. Electrocardiogram was monitored every 5 minutes using limb lead II throughout the experiment. Incidence and severity of arrhythmias were analysed from ECG recordings. Results: Metoprolol in all doses produced slight bradycardia and percent protection against arrhythmias was 0 to 16.6% with different doses.Percent protection produced by prazosin was 33.3 to 66.6%. When metoprolol (lowest dose) was used in combination with prazosin (lowest dose) there was no change in heart rate and percent protection against arrhythmias was 83.3%. Conclusion: Combination of a cardioselective beta blocker (metoprolol) and an alpha blocker (prazosin) has produced potentiation of effect in protecting the heart against reperfusion induced arrhythmias in intact rabbit heart.


How to cite this article:
Sharma D, Pandhi P. Effect of metoprolol and prazosin alone and in combination in reperfusion induced arrhythmias in intact rabbits.Indian J Pharmacol 1997;29:310-313


How to cite this URL:
Sharma D, Pandhi P. Effect of metoprolol and prazosin alone and in combination in reperfusion induced arrhythmias in intact rabbits. Indian J Pharmacol [serial online] 1997 [cited 2021 Sep 19 ];29:310-313
Available from: https://www.ijp-online.com/article.asp?issn=0253-7613;year=1997;volume=29;issue=5;spage=310;epage=313;aulast=Sharma;type=0