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| Year : 1997 | Volume
: 29
| Issue : 2 | Page : 135--137 |
Comparative bioavailability of two brands of cyclosporin
A Sachdeva1, R Gulati2, U Gupta3, JS Bapna4
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Correspondence Address:
A Sachdeva
Objectives: To compare the pharmacokinetics of two brands of oral cyclosporin solution was compared in healthy male volunteers.
Methods: A single oral dose of 15mg/kg of either test or reference preparations of cyclosporin was administered to all the volunteers in double blind randomised cross over fashion. Plasma levels of cyclosporin were analysed using HPLC.
Results: The mean peak plasma cyclosporin concentration of 654.4ng/ml was observed at 3.39h with test brand and was similar to that of reference brand with Cmax of 628.61ng/ml at 3.43h. The differences between the pharmacokinetic parameters of two brands of cyclosporin were statistically in significant.
Conclusion: Both the brands of cyclosporin can be considered to be bioequivalent on the basis of the results obtained.
How to cite this article:
Sachdeva A, Gulati R, Gupta U, Bapna J S. Comparative bioavailability of two brands of cyclosporin.Indian J Pharmacol 1997;29:135-137
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How to cite this URL:
Sachdeva A, Gulati R, Gupta U, Bapna J S. Comparative bioavailability of two brands of cyclosporin. Indian J Pharmacol [serial online] 1997 [cited 2022 Aug 9 ];29:135-137
Available from: https://www.ijp-online.com/article.asp?issn=0253-7613;year=1997;volume=29;issue=2;spage=135;epage=137;aulast=Sachdeva;type=0 |
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