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Year : 1996  |  Volume : 28  |  Issue : 4  |  Page : 265--268

Antiulcerogenic effect of UL-409 against experimentally induced gastric ulcer in rats

AJ Vanisree1, K Mitra2, Devi CS Shyamala3 
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A J Vanisree


An aqueous suspension of a herbal drug formulation (UL-409) was tested in male Wistar rats for antiulcerogenic activity. The drug formulation displayed cytoprotective action against experimentally induced peptic ulcer. A daily dose of 600 mg/kg body weight of the formulation orally for 30 days decreased the number of ulcerative lesions, prevented the increased lipid peroxidation and enhanced the activities of antioxidant enzymes namely, superoxide dismutase, catalase and glutathione peroxidase along with the reduction in the consumption of glutathione. Since UL-409 reduced the damage caused by HCl/ethanol and increased the activities of scavenging enzymes, it is concluded that its antiulcerogenic activity is mediated through antioxidant defense mechanism.


How to cite this article:
Vanisree A J, Mitra K, Shyamala DC. Antiulcerogenic effect of UL-409 against experimentally induced gastric ulcer in rats.Indian J Pharmacol 1996;28:265-268


How to cite this URL:
Vanisree A J, Mitra K, Shyamala DC. Antiulcerogenic effect of UL-409 against experimentally induced gastric ulcer in rats. Indian J Pharmacol [serial online] 1996 [cited 2021 Dec 5 ];28:265-268
Available from: https://www.ijp-online.com/article.asp?issn=0253-7613;year=1996;volume=28;issue=4;spage=265;epage=268;aulast=Vanisree;type=0