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Year : 1996  |  Volume : 28  |  Issue : 4  |  Page : 254--256

Impairment of glycerol 3-phosphate shuttle by methyl isocyanate in rats

K Jeevaratnam 
 

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K Jeevaratnam


The present study describes the effect of methyl isocyanate (MIC) on the hepatic glycerol 3-phosphate shuttle. Addition of MIC to the isolated rat liver mitochondria in vitro resulted in a dose-dependent inhibition of glycerol 3-phosphate dehydrogenase. Subcutaneous ad-ministration of MIC at lethal dose to rats caused a significant effect on hepatic glycerol 3- phosphate shuttle. There was a significant inhibition of both mitochondrial and cytosolic glycerol 3-phosphate dehydrogenase indicating the impairment of translocation of the reducing equivalents, NADH into the mitochondria.


How to cite this article:
Jeevaratnam K. Impairment of glycerol 3-phosphate shuttle by methyl isocyanate in rats.Indian J Pharmacol 1996;28:254-256


How to cite this URL:
Jeevaratnam K. Impairment of glycerol 3-phosphate shuttle by methyl isocyanate in rats. Indian J Pharmacol [serial online] 1996 [cited 2021 Nov 30 ];28:254-256
Available from: https://www.ijp-online.com/article.asp?issn=0253-7613;year=1996;volume=28;issue=4;spage=254;epage=256;aulast=Jeevaratnam;type=0