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Year : 1996  |  Volume : 28  |  Issue : 2  |  Page : 88--92

Optimizing dosage regimens of liposomal amphotericin B using aspergillus murine model

RN Kotwani1, PC Gokhale2, NA Kshirsagar3, SK Pandya4 
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Correspondence Address:
R N Kotwani


Amphotericin B remains the drug of choice in most systemic mycoses, but its use is often limited by its severe side effects. Liposomal encapsulation of amphotericin B has been shown to improve tolerance without compromising efficacy. In this study, the dosage regimens and frequency of administration of liposomal amphotericin B prepared using soya phosphatidylcholine and cholesterol given prophylactically or therapeutically in mice infected with Aspergillus fumigatus was assessed. Liposomal amphotericin B was more effective than free amphotericin B on an equal dose basis when given therapeutically. A large single dose of liposomal amphotericin B was more effective, both prophylactically and therapeutically, than two divided doses of the total dose.


How to cite this article:
Kotwani R N, Gokhale P C, Kshirsagar N A, Pandya S K. Optimizing dosage regimens of liposomal amphotericin B using aspergillus murine model.Indian J Pharmacol 1996;28:88-92


How to cite this URL:
Kotwani R N, Gokhale P C, Kshirsagar N A, Pandya S K. Optimizing dosage regimens of liposomal amphotericin B using aspergillus murine model. Indian J Pharmacol [serial online] 1996 [cited 2022 Aug 10 ];28:88-92
Available from: https://www.ijp-online.com/article.asp?issn=0253-7613;year=1996;volume=28;issue=2;spage=88;epage=92;aulast=Kotwani;type=0