Indian Journal of Pharmacology Home 

SHORT COMMUNICATION
[Download PDF]
Year : 1996  |  Volume : 28  |  Issue : 2  |  Page : 120--122

Synthesis and preliminary cardiovascular activity of some phenoxypropanolamines as beta blockers

J Kannan1, R Giridhar2, R Balaraman3 
1 
2 
3 

Correspondence Address:
J Kannan


Three compounds of phenoxypropanolamine type with chlorine substituted at para (Compound I: PCP) and ortho (Compound II: OCP) positions and without chlorine (Compound III: NCP) were synthesised and characterised by their physical and chemical methods. All the three compounds significantly (P<0.001) reduced the tachycardia induced by isoprenaline in dogs and rats while compound I and compound II significantly (P<0.001) blocked the isoprenaline induced fall in blood pressure implying a non-selective beta, and beta, blocking effect in both species. Compound III did not block the isoprenaline induced fall in blood pressure in both the animals implying a selective beta, action. The blockade produced by compound I & II (2 x 10-6 M) were similar to the effect produced by propranolol (2 x 10-6 M).


How to cite this article:
Kannan J, Giridhar R, Balaraman R. Synthesis and preliminary cardiovascular activity of some phenoxypropanolamines as beta blockers.Indian J Pharmacol 1996;28:120-122


How to cite this URL:
Kannan J, Giridhar R, Balaraman R. Synthesis and preliminary cardiovascular activity of some phenoxypropanolamines as beta blockers. Indian J Pharmacol [serial online] 1996 [cited 2022 Aug 10 ];28:120-122
Available from: https://www.ijp-online.com/article.asp?issn=0253-7613;year=1996;volume=28;issue=2;spage=120;epage=122;aulast=Kannan;type=0