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Year : 1996  |  Volume : 28  |  Issue : 2  |  Page : 110--112

Contractile activity of Alstonia boonei stem bark extract on isolated rat stomach strip and guinea pig ileum

JM Makinde1, OB Taiwo2 
1 
2 

Correspondence Address:
J M Makinde


The effect of lyophylized aqueous extract of Alstonia boonei stem bark was investigated on guinea pig ileum and rat stomach strip. The extract had a contractile effect on both smooth muscles; the effect was more on rat stomach strip than on guinea pig ileum. Pre-incubation of the stomach strip preparation did not inhibit the extract induced tonic contractions. On the other hand, the contraction induced by the extract was antagonised by methysergide in a competitive manner suggesting a role for 5-HT in the biological effect of the extract.


How to cite this article:
Makinde J M, Taiwo O B. Contractile activity of Alstonia boonei stem bark extract on isolated rat stomach strip and guinea pig ileum.Indian J Pharmacol 1996;28:110-112


How to cite this URL:
Makinde J M, Taiwo O B. Contractile activity of Alstonia boonei stem bark extract on isolated rat stomach strip and guinea pig ileum. Indian J Pharmacol [serial online] 1996 [cited 2022 Aug 10 ];28:110-112
Available from: https://www.ijp-online.com/article.asp?issn=0253-7613;year=1996;volume=28;issue=2;spage=110;epage=112;aulast=Makinde;type=0