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Year : 1996  |  Volume : 28  |  Issue : 2  |  Page : 102--106

Role of central serotonergic system in immunomodulation in rats

D Kumar1, HC Tripathi2, SK Mishra3, SK Tandan4, V Raviprakash5, SC Mishra6 
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Correspondence Address:
D Kumar


5-hydroxytryptophan (5-HTP), a precursor of serotonin and para chlorophenylalanine (PCPA), a serotonin synthesis blocker, were administered centrally in immunized rats to investigate the role of central serotonergic system in immunomodulation. 5-HTP treatment prior to immunization significantly inhibited the cell mediated as well as humoral immune response. However, plasma corticosterone levels remained unaffected. Post-immunization treatment with 5-HTP did not produce any effect on immune response and plasma corticosterone levels. PCPA administered prior to immunization markedly stimulated the cell-mediated as well as humoral immune response but there was no effect on plasma corticosterone levels.Cell mediated immune response was, however, reduced significantly with a concomitant increase in the plasma corticosterone levels in the rats treated with PCPA after immunization. It is suggested that the central serotonergic system plays a critical role in immunomodulation.


How to cite this article:
Kumar D, Tripathi H C, Mishra S K, Tandan S K, Raviprakash V, Mishra S C. Role of central serotonergic system in immunomodulation in rats.Indian J Pharmacol 1996;28:102-106


How to cite this URL:
Kumar D, Tripathi H C, Mishra S K, Tandan S K, Raviprakash V, Mishra S C. Role of central serotonergic system in immunomodulation in rats. Indian J Pharmacol [serial online] 1996 [cited 2022 Aug 13 ];28:102-106
Available from: https://www.ijp-online.com/article.asp?issn=0253-7613;year=1996;volume=28;issue=2;spage=102;epage=106;aulast=Kumar;type=0