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Year : 1996  |  Volume : 28  |  Issue : 1  |  Page : 29--31

Pro-inflammatory and pro-algesic effect of icv administered Substance P in rats

VK Dumka1, SK Tandan2, HC Tripathi3, V Raviprakash4 
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Correspondence Address:
V K Dumka


The central modulatory role of substance P following its icv administration (50 ęg) was studied on formaldehyde-induced paw oedema and nociception in rats. A significant accentuation of oedema volume was shown along with proalgesic effect on formaldehyde-induced inflammation. A corresponding increase was also observed in protein content of the inflammatory exudate. The study confirms the pro inflammatory effect of substance P.


How to cite this article:
Dumka V K, Tandan S K, Tripathi H C, Raviprakash V. Pro-inflammatory and pro-algesic effect of icv administered Substance P in rats.Indian J Pharmacol 1996;28:29-31


How to cite this URL:
Dumka V K, Tandan S K, Tripathi H C, Raviprakash V. Pro-inflammatory and pro-algesic effect of icv administered Substance P in rats. Indian J Pharmacol [serial online] 1996 [cited 2023 Oct 4 ];28:29-31
Available from: https://www.ijp-online.com/article.asp?issn=0253-7613;year=1996;volume=28;issue=1;spage=29;epage=31;aulast=Dumka;type=0