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Year : 1995  |  Volume : 27  |  Issue : 3  |  Page : 195--196

Does ethanol release acetylcholine to produce contraction on isolated frog rectus abdominis?

AK Kela1, AK Sharma2, VL Mehta3 
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Correspondence Address:
A K Kela


Ethanol has been shown to contract isolated frog rectus abdominis in a dose-dependent manner and it has been suggested that acetylcholine (Ach) or Ach like neurotransmitter may be responsible for these contractions. To confirm it further, the present work was undertaken. Agents used in the study were hemicholinium, vecuronium and physostigmine. It was observed that hemicholinium (10-5M) inhibited ethanol induced contraction, suggesting action of ethanol through cholinergic mechanisms rather than a direct action. Vecuronium (10-5M) exhibited a non-competitive antagonism with ethanol, while physostigmine (10-5M) did not potentiate ethanol - induced contraction, suggesting that ethanol acts by release of Ach-like substance the nature of which needs to be determined


How to cite this article:
Kela A K, Sharma A K, Mehta V L. Does ethanol release acetylcholine to produce contraction on isolated frog rectus abdominis?.Indian J Pharmacol 1995;27:195-196


How to cite this URL:
Kela A K, Sharma A K, Mehta V L. Does ethanol release acetylcholine to produce contraction on isolated frog rectus abdominis?. Indian J Pharmacol [serial online] 1995 [cited 2021 Oct 19 ];27:195-196
Available from: https://www.ijp-online.com/article.asp?issn=0253-7613;year=1995;volume=27;issue=3;spage=195;epage=196;aulast=Kela;type=0