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Year : 1995  |  Volume : 27  |  Issue : 3  |  Page : 178--182

Suppression of exploration and locomotion by central nervous system stimulants

AK Agarwal 
 

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A K Agarwal


Exploration and locomotion was studied on a hole-board following intraperitoneal administration of CNS stimulants in mice. Each drug was studied at 3 dose levels after 5, 30 and 60 minutes of injection. Head-dip count in 5 min was taken as an index of exploration and squares crossed gave the locomotion score. All stimulant drugs significantly suppressed head dipping except caffeine (5 mg/kg) and leptazol (10 mg/kg). Locomotion was also decreased but to a variable degree except with amphetamine (2 and 4 mg/kg) and caffeine (10 and 20 mg/kg) which increased locomotor activity, and picrotoxin causing no significant change. The results reflect an anxiogenic profile of CNS stimulant drugs in animal model of anxiety with probable involvement of central dopaminergic system.


How to cite this article:
Agarwal A K. Suppression of exploration and locomotion by central nervous system stimulants.Indian J Pharmacol 1995;27:178-182


How to cite this URL:
Agarwal A K. Suppression of exploration and locomotion by central nervous system stimulants. Indian J Pharmacol [serial online] 1995 [cited 2022 Dec 2 ];27:178-182
Available from: https://www.ijp-online.com/article.asp?issn=0253-7613;year=1995;volume=27;issue=3;spage=178;epage=182;aulast=Agarwal;type=0