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Year : 1994  |  Volume : 26  |  Issue : 4  |  Page : 296--300

Effect of diterpenes from Andrographis paniculata on antioxidant defense system and lipid peroxidation

IB Koul1, A Kapil2 
1 
2 

Correspondence Address:
I B Koul


In the present study, the effect of the diterpenes i.e., andrographolide (I), andrographiside (II) and neoandrographolide (Ill) from Andrographis paniculata was investigated on the hepatocellular antioxidant defense system in CCl4 - treated mice. lntraperitoneal administration of the diterpenes at a dose of 100 mg/kg b.wt for 7 days caused a significant elevation in different components of cellular antioxidant defense and reduction in lipid peroxidation, revealing that the antioxidant action may play a role in the antihepatotoxic activity of the diterpenes. A comparison with silymarin, a standard hepatoprotective agent, showed that Ill was as effective as silymarin (SM) with respect to its effect on reduced glutathione (GSH), glutathione S-transferase (GST), glutathione peroxidase (GSH-Px) and superoxide dismutase (SOD) in the intoxicated animals, whereas in II treated group only antilipoperoxidant response was as prominent as that of SM treated group.


How to cite this article:
Koul I B, Kapil A. Effect of diterpenes from Andrographis paniculata on antioxidant defense system and lipid peroxidation.Indian J Pharmacol 1994;26:296-300


How to cite this URL:
Koul I B, Kapil A. Effect of diterpenes from Andrographis paniculata on antioxidant defense system and lipid peroxidation. Indian J Pharmacol [serial online] 1994 [cited 2022 Aug 19 ];26:296-300
Available from: https://www.ijp-online.com/article.asp?issn=0253-7613;year=1994;volume=26;issue=4;spage=296;epage=300;aulast=Koul;type=0