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Year : 1994  |  Volume : 26  |  Issue : 3  |  Page : 190--193

Effects of combined H1 and H2 blockers activity against histamine Induced bronchospasm in guinea pigs

J Jena1, Q Ahmed2, PK Kar3 
1 
2 
3 

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J Jena


Both H1 and H2 blockers were studied for their protective action against histamine aerosol induced bronchospasm in guinea pigs, The H1 blockers produced significant dose dependant complete protection in some animals and significant prolongation of the exposition time in the remaining animals. Diphenhydramine was taken as the standard. The H2 blocker cimetidine also produced the same effects as the H, blockers. When both diphenhydramine and cimetidine were administered together additive effect was produced with highly significant complete protection in some animals and significant prolongation of the exposition times in the remaining animals. This suggests involvement of both H, and H2 receptors in production of histamine induced bronchospasm in guineapigs.


How to cite this article:
Jena J, Ahmed Q, Kar P K. Effects of combined H1 and H2 blockers activity against histamine Induced bronchospasm in guinea pigs.Indian J Pharmacol 1994;26:190-193


How to cite this URL:
Jena J, Ahmed Q, Kar P K. Effects of combined H1 and H2 blockers activity against histamine Induced bronchospasm in guinea pigs. Indian J Pharmacol [serial online] 1994 [cited 2022 Jul 2 ];26:190-193
Available from: https://www.ijp-online.com/article.asp?issn=0253-7613;year=1994;volume=26;issue=3;spage=190;epage=193;aulast=Jena;type=0