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Year : 1994  |  Volume : 26  |  Issue : 1  |  Page : 52--54

Antagonistic effects of several adrenergic blocking agents on ventricular Tachycardia induced by benzene and adrenaline in rat

GP Thomas1, MUR Naidu2, RM Tripathi3, RK Tripathi4, RK Varma5 
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Correspondence Address:
G P Thomas


Several adrenergic antagonists such as phenoxybenzamine and phentolamine (non-specific alpha), prazosin (alpha1), yohimbine (alpha2), propranolol (non-specific beta with membrane stabilizing action), practolol (cardioselective beta), sotalol (non selective beta with no membrane stabilizing action) and labetalol (non selective beta with alpha1 blocking action) were studied for their effects on ventricular tachycardias induced by benzene and adrenaline in anaesthetised rats. All the alpha and beta adrenergic blocking agents examined showed significant antiarrhythmic effect in this model. The relative potencies of alpha blockers were: prazosin > yohimbine > phenoxybenzamine > phentolamine while that of beta blockers were:labetalol > propranolol > practolol > sotalol.


How to cite this article:
Thomas G P, Naidu M, Tripathi R M, Tripathi R K, Varma R K. Antagonistic effects of several adrenergic blocking agents on ventricular Tachycardia induced by benzene and adrenaline in rat.Indian J Pharmacol 1994;26:52-54


How to cite this URL:
Thomas G P, Naidu M, Tripathi R M, Tripathi R K, Varma R K. Antagonistic effects of several adrenergic blocking agents on ventricular Tachycardia induced by benzene and adrenaline in rat. Indian J Pharmacol [serial online] 1994 [cited 2022 Jan 27 ];26:52-54
Available from: https://www.ijp-online.com/article.asp?issn=0253-7613;year=1994;volume=26;issue=1;spage=52;epage=54;aulast=Thomas;type=0