RESEARCH PAPER |
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| Year : 1993 | Volume
: 25
| Issue : 4 | Page : 224--227 |
Evidence for alpha-2 adrenoceptor agonist activity of hydralazine
MC Satia1, RK Goyal2
1
2
Correspondence Address:
M C Satia
Hydralazine (5.08 x 10-5 M to 1.5 x 10-3M ) produced a dose-dependent inhibition of field stimulation evoked responses on rat anococcygeus muscle and vas-deferens. This was antagonized competitively by yohimbine. On estrogen primed rat uterus, hydralazine produced a dose-dependent relaxation which was competitively blocked by yohimbine and propranolol but not by cimetidine. The responses to hydralazine were significantly inhibited by reserpine pre-treatment (5mg/kg, i.p., 24 h. before). Our data suggests alpha2-adrenoceptor agonist activity of hydralazine.
How to cite this article:
Satia M C, Goyal R K. Evidence for alpha-2 adrenoceptor agonist activity of hydralazine.Indian J Pharmacol 1993;25:224-227
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How to cite this URL:
Satia M C, Goyal R K. Evidence for alpha-2 adrenoceptor agonist activity of hydralazine. Indian J Pharmacol [serial online] 1993 [cited 2023 Feb 9 ];25:224-227
Available from: https://www.ijp-online.com/article.asp?issn=0253-7613;year=1993;volume=25;issue=4;spage=224;epage=227;aulast=Satia;type=0 |
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