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Year : 1993  |  Volume : 25  |  Issue : 4  |  Page : 188--192

Medetomidine - A new selective alpha-2 adrenoceptor agonist

BV Venkataraman1, MA Nagarani2 
1 
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Correspondence Address:
B V Venkataraman


Medetomidine, an imidazoline derivative is a lipophilic compound with selective (2-adrenoceptor agonist activity. It has a negligible binding affinity for dopaminergic, cholinergic, histaminergic, opiate, adenosine and benzodiazepine receptors. Various in vivo experiments show dose-dependent hypotensive, bradycardia, sedative, anxiolytic, mydriatic, hypothermic and analgesic effects. In general it is more potent than the other an-agonists in central and peripheral actions on (2-adrenoceptors. Effects of medetomidine can be antagonised by prior, simultaneous or subsequent administration of an-antagonists. In human trials it is shown to be well tolerated and the drug may also have therapeutic applications in humans.


How to cite this article:
Venkataraman B V, Nagarani M A. Medetomidine - A new selective alpha-2 adrenoceptor agonist.Indian J Pharmacol 1993;25:188-192


How to cite this URL:
Venkataraman B V, Nagarani M A. Medetomidine - A new selective alpha-2 adrenoceptor agonist. Indian J Pharmacol [serial online] 1993 [cited 2023 Feb 8 ];25:188-192
Available from: https://www.ijp-online.com/article.asp?issn=0253-7613;year=1993;volume=25;issue=4;spage=188;epage=192;aulast=Venkataraman;type=0