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Year : 1993  |  Volume : 25  |  Issue : 1  |  Page : 30--33

Local anesthetic activity of some basicamide compounds

NA Kalra1, RV Bhatt2, U Trivedi3, JJ Trivedi4, RK Goyal5 
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Correspondence Address:
N A Kalra


Basic amide hydrochloride compounds were found to be potent local anesthetics (100% potency), with onset of action comparable with lignocaine. Within a series, duration of anesthesia was found to increase with the increase in hydrocarbon chain length attached to DQthioDQ moiety. Compounds B to E and H which were found to be potent local anesthetics, also possessed potent vasoconstrictor activity. The correlation coefficient between vasoconstridor activity and duration of local anesthetic activity was found to be 0.6. The Ld50 values as determined by acute toxicity studies in mice was greater than 22.4 mg/kg. Our data suggest that basicamide HCI compounds with DQthioDQ moiety possess local anesthetic agent of greater potency and duration.


How to cite this article:
Kalra N A, Bhatt R V, Trivedi U, Trivedi J J, Goyal R K. Local anesthetic activity of some basicamide compounds.Indian J Pharmacol 1993;25:30-33


How to cite this URL:
Kalra N A, Bhatt R V, Trivedi U, Trivedi J J, Goyal R K. Local anesthetic activity of some basicamide compounds. Indian J Pharmacol [serial online] 1993 [cited 2023 Feb 3 ];25:30-33
Available from: https://www.ijp-online.com/article.asp?issn=0253-7613;year=1993;volume=25;issue=1;spage=30;epage=33;aulast=Kalra;type=0