Indian Journal of Pharmacology Home 

RESEARCH PAPER
[Download PDF]
Year : 1992  |  Volume : 24  |  Issue : 2  |  Page : 111--113

To compare the efficacy of atenolol and acebutolol on isometric exercise - induced hemodynamic changes

Lal Avtar1, CR Giriappanavar2, SK Tripathi3, NR Biswas4, PL Sharma5 
1 
2 
3 
4 
5 

Correspondence Address:
Lal Avtar


: The efficacy of atenolol (single dose 50 mg and multiple doses 50 mg bid x 5 days) and acebutolol (single dose 200 mg and multiple doses 200 mg bid x 5 days), on Isometric excercise (IME) -induced changes in systolic blood pressure (SDP), diastolic blood pressure (DBP), heart rate (HH), HR-SBP product and maximum oxygen consumption (MV02) was studied in 6 healthy volunteers, in a controlled, randomized, double blind and cross over study. Atenolol in multiple doses caused significant lowering of IME- induced rise in SBP and DBP (P < 0.02 and P < 0.01 respectivelv). The single dose of acebutolol caused significant decrease in IME-induced increase in SBP and DBP (P < 0.01 and P < 0.05 respectively) and in multiple doses caused significant fall in IME-Induced DBP (P < 0.02). Atenolol caused significant decrease in IME-induced rise in HR, both by its«SQ» single and multiple doses (P < 0.0l), whereas acebutolol lowered it significantly only in single dose (P < 0.05). Comparison of reduction by atenolol and acebutolol on IME-induced hemodynamic changes reveals that atenolol is superior to acebutolol


How to cite this article:
Avtar L, Giriappanavar C R, Tripathi S K, Biswas N R, Sharma P L. To compare the efficacy of atenolol and acebutolol on isometric exercise - induced hemodynamic changes.Indian J Pharmacol 1992;24:111-113


How to cite this URL:
Avtar L, Giriappanavar C R, Tripathi S K, Biswas N R, Sharma P L. To compare the efficacy of atenolol and acebutolol on isometric exercise - induced hemodynamic changes. Indian J Pharmacol [serial online] 1992 [cited 2022 Jul 5 ];24:111-113
Available from: https://www.ijp-online.com/article.asp?issn=0253-7613;year=1992;volume=24;issue=2;spage=111;epage=113;aulast=Avtar;type=0