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Year : 1991  |  Volume : 23  |  Issue : 4  |  Page : 247--252

Evidences for the presence of dopamine receptors in iris

YP Srivastava1, BB Lal2, CD Tripathi3 
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2 
3 

Correspondence Address:
Y P Srivastava


1. Haloperidol is known to produce miosis by acting on receptors present in the iris. This study domonstrates the presence of dopamine receptors in the iris. 2. Dopamine given intracamerally produced dose-related mydriasis, and haloperidol was found to competitively antagonize this effect. 3. Apomorphine, another dopamine agonist, also produced dose-related mydriasis. 4. These observations suggest the presence of dopamine receptors in the iris. 5. Since the mydriasis was completely abolished after reserpinization and competetively antagonixed by phentolamine, it is proposed that these dopamine receptors are present presynaptically at the sympathetic nerve endings and are excitatory for norepinephrine release.


How to cite this article:
Srivastava Y P, Lal B B, Tripathi C D. Evidences for the presence of dopamine receptors in iris.Indian J Pharmacol 1991;23:247-252


How to cite this URL:
Srivastava Y P, Lal B B, Tripathi C D. Evidences for the presence of dopamine receptors in iris. Indian J Pharmacol [serial online] 1991 [cited 2022 Jul 2 ];23:247-252
Available from: https://www.ijp-online.com/article.asp?issn=0253-7613;year=1991;volume=23;issue=4;spage=247;epage=252;aulast=Srivastava;type=0