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Year : 1991  |  Volume : 23  |  Issue : 4  |  Page : 214--218

Study of effects of oral contraceptive steroids on experimentally induced ulcers in rat stomach

K Chakravarty1, BP Mukherjee2 
1 
2 

Correspondence Address:
K Chakravarty


1. Three categories of oral contraceptive agents viz., estrogen, progestogen and combination of these two were administered p.o. to separate groups of female albino rats for graded time schedules to evaluate the effects on stress-induced gastric lesions. 2. Under estrogen regime prolongation of drug therapy afforded increasing degree of protection. 3. Progestogen was ineffective in preventing the lesions in short-term medication, but produced even grater protection than with estrogen during long-term schedule. 4. In case of combination pill therapy, the results were opposite to that of progestogen. 5. Varying degrees of effects on gastric acidity, mucus secretion and possible inhibitory influence on hypothalamic control could be responsible for the differential effects of the agents used.


How to cite this article:
Chakravarty K, Mukherjee B P. Study of effects of oral contraceptive steroids on experimentally induced ulcers in rat stomach.Indian J Pharmacol 1991;23:214-218


How to cite this URL:
Chakravarty K, Mukherjee B P. Study of effects of oral contraceptive steroids on experimentally induced ulcers in rat stomach. Indian J Pharmacol [serial online] 1991 [cited 2022 Jun 29 ];23:214-218
Available from: https://www.ijp-online.com/article.asp?issn=0253-7613;year=1991;volume=23;issue=4;spage=214;epage=218;aulast=Chakravarty;type=0