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Year : 1989  |  Volume : 21  |  Issue : 3  |  Page : 104--106

Modification of histamine induced wheal suppression method and its utility in bioassay of topical steroids

PK Singh1, G Singh2 
1 
2 

Correspondence Address:
P K Singh


1. Histamine induced wheal suppression technique of Reddy and Singh (1976) has been modified by calculating volume of the wheal. 2. Height of the wheal was measured with the help of a spherometer to calculate its volume by the relation (r2h. 3. Potency of two topical corticosteroid preparations (halcinonide 0.1% and hydrocortisone l .0%) was assessed on ten healthy volunteers in a double blind study. 4. The effect of tachyphylaxis was observed with both the steroids within a week, still earlier with potent steroid.A four days rest was enough to bring back the skin to its pretreatment level.


How to cite this article:
Singh P K, Singh G. Modification of histamine induced wheal suppression method and its utility in bioassay of topical steroids.Indian J Pharmacol 1989;21:104-106


How to cite this URL:
Singh P K, Singh G. Modification of histamine induced wheal suppression method and its utility in bioassay of topical steroids. Indian J Pharmacol [serial online] 1989 [cited 2022 Aug 19 ];21:104-106
Available from: https://www.ijp-online.com/article.asp?issn=0253-7613;year=1989;volume=21;issue=3;spage=104;epage=106;aulast=Singh;type=0