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Year : 1989  |  Volume : 21  |  Issue : 2  |  Page : 16--21

Potential antifilarial activity of Streblus asper against Setaria cervi (nematoda: filarioidea)

Parveen Nazneen1, KC Singhal2, NU Khan3, Singhal Parul4 
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Correspondence Address:
Parveen Nazneen


The effect of aqueous and alcoholic extract of Streblus asper was studied on the spontaneous movements of the whole worm and nerve-muscle preparation of Setaria cervi and on the survival of microfilariae in vitro. Aqueous as well as alcoholic extract caused inhibition of spontaneous motility of the whole worm and the nerve-muscle preparation of S cervi characterized by decreased tone, amplitude and rate of contractions. The concentration required to inhibit the movements of the nerve-muscle preparation was l/25 for aqueous and l/160 for alcoholic extract suggesting a cuticular permeability barrrier. The stimulatory response of acetylcholine was blocked by alcoholic and not by aqueous extract of S asper. Both alcoholic as well as aqueous extracts caused death of microfilariae in vitro, LC50 and LC90 being 90 and 33.5 ng/ml, respectively.


How to cite this article:
Nazneen P, Singhal K C, Khan N U, Parul S. Potential antifilarial activity of Streblus asper against Setaria cervi (nematoda: filarioidea).Indian J Pharmacol 1989;21:16-21


How to cite this URL:
Nazneen P, Singhal K C, Khan N U, Parul S. Potential antifilarial activity of Streblus asper against Setaria cervi (nematoda: filarioidea). Indian J Pharmacol [serial online] 1989 [cited 2021 Nov 27 ];21:16-21
Available from: https://www.ijp-online.com/article.asp?issn=0253-7613;year=1989;volume=21;issue=2;spage=16;epage=21;aulast=Nazneen;type=0