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Year : 1988  |  Volume : 20  |  Issue : 2  |  Page : 178--181

-Lactam antibiotics: effect on barbiturate-induced hypnosis in mice

PP Singh1, AY Junnarkar2, KV Singh3, NP Shukla4 
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Correspondence Address:
P P Singh


1. In the present investigation the effect of few (-Iactam antibiotics end their intermediates were studied on the barbiturate induced hypnosis in mice. 2. Sodium ampicillin, amoxicillin end 7-aminodeacetoxy cephalosporanic acid failed to inhibit herbitone-induced hypnosis and animals pretreated 2 end 12 h before did not affect the pentabarbitone sleeping time. indicating the induction of hepatic microsomal enzyme bythese agents end which is a slow process.


How to cite this article:
Singh P P, Junnarkar A Y, Singh K V, Shukla N P. -Lactam antibiotics: effect on barbiturate-induced hypnosis in mice.Indian J Pharmacol 1988;20:178-181


How to cite this URL:
Singh P P, Junnarkar A Y, Singh K V, Shukla N P. -Lactam antibiotics: effect on barbiturate-induced hypnosis in mice. Indian J Pharmacol [serial online] 1988 [cited 2021 Sep 25 ];20:178-181
Available from: https://www.ijp-online.com/article.asp?issn=0253-7613;year=1988;volume=20;issue=2;spage=178;epage=181;aulast=Singh;type=0