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|Year : 1988 | Volume
| Issue : 2 | Page : 122--128
Influence of temperature on the status of histamine receptors in the isolated guinea pig ileum
PK Bhuttani1, RJ Shah2, KR Goyal3
1. Histamine a non-specific H-receptor agonist & 2 (2-pyridyl) ethylamine (PEA).an H1 receptor agonist produced dose dependent contractions of guinea-pig ileum at 37«DQ». 25«DQ» and 15ø C.
2. The responses were blocked competitively by mepyramine (1 X 10-9 M) at 37oC and 25ø C. The antagonism appeared to be non-competitive at 15ø C.
3. Ranitidine (1 X 10 -7M) inhibited the responses to histamine at all temperatures.
4. Dimaprit, a specific H2 receptor agonist did not produce any effect at 37øC. However at 25øC and 15øC. it produced a dose dependent contraction and the responses were competitively blocked by rantidine.
5. Our data suggests decrease in H1-receptors and appearance of excitatory H2-receptors at lower temperatures in guinea pigileum. ,
P K Bhuttani
|How to cite this article:|
Bhuttani P K, Shah R J, Goyal K R. Influence of temperature on the status of histamine receptors in the isolated guinea pig ileum.Indian J Pharmacol 1988;20:122-128
|How to cite this URL:|
Bhuttani P K, Shah R J, Goyal K R. Influence of temperature on the status of histamine receptors in the isolated guinea pig ileum. Indian J Pharmacol [serial online] 1988 [cited 2021 Sep 20 ];20:122-128
Available from: https://www.ijp-online.com/article.asp?issn=0253-7613;year=1988;volume=20;issue=2;spage=122;epage=128;aulast=Bhuttani;type=0