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Year : 1987  |  Volume : 19  |  Issue : 1  |  Page : 44--48

Local anaesthetic activity of 9-alkylamino-1,2,3,4,-tetrahydroacridines: structure-activity relationship study

SN Rastogi1, GK Patnaik2, BN Dhawan3 
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Correspondence Address:
S N Rastogi


1. A series of 9-alkylamino-1, 2, 3, 4-tetrahydroacridines and analogues were synthesized and tested for local ansesthetic activity in rabbits and guinea pigs. 2. 9-n-Heptylamino-1, 2, 3, 4-tetrahydroacridines showed the maximum activity and were more potent than lignocaine. 3. The local anaesthetic activity seems to be partly influenced by the lipophilicity of the compounds.


How to cite this article:
Rastogi S N, Patnaik G K, Dhawan B N. Local anaesthetic activity of 9-alkylamino-1,2,3,4,-tetrahydroacridines: structure-activity relationship study.Indian J Pharmacol 1987;19:44-48


How to cite this URL:
Rastogi S N, Patnaik G K, Dhawan B N. Local anaesthetic activity of 9-alkylamino-1,2,3,4,-tetrahydroacridines: structure-activity relationship study. Indian J Pharmacol [serial online] 1987 [cited 2021 Dec 1 ];19:44-48
Available from: https://www.ijp-online.com/article.asp?issn=0253-7613;year=1987;volume=19;issue=1;spage=44;epage=48;aulast=Rastogi;type=0