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Year : 1986  |  Volume : 18  |  Issue : 2  |  Page : 104--106

Plasma prostaglandin levels in febrile illnesses

KP Gupta1, SG Tiwari2, A Gupta3 
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Correspondence Address:
K P Gupta


1. Plasma prostaglandin levels were estimated in 13 normal individuals and in 35 patients suffering from febrile illnesses due to short viral fever, viral hepatitis, amoebic liver abscess, transfusion reaction, lobar pneumonia, enteric fever, acute malarial fever and pulmonary tuberculosis. 2. In all cases of febrile illnesses there was 2-5 fold increase in plasma prostaglandin levels which again came down to normal after oral administration of paracetamol or when the fever subsided itself. 3. The findings suggest that there is increased synthesis/release of prostaglandins in the blood which crosses the blood brain barrier to act upon the pre-optic anterior hypothalamus to produce fever.


How to cite this article:
Gupta K P, Tiwari S G, Gupta A. Plasma prostaglandin levels in febrile illnesses.Indian J Pharmacol 1986;18:104-106


How to cite this URL:
Gupta K P, Tiwari S G, Gupta A. Plasma prostaglandin levels in febrile illnesses. Indian J Pharmacol [serial online] 1986 [cited 2023 Sep 25 ];18:104-106
Available from: https://www.ijp-online.com/article.asp?issn=0253-7613;year=1986;volume=18;issue=2;spage=104;epage=106;aulast=Gupta;type=0