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|Year : 1986 | Volume
| Issue : 1 | Page : 9--13
Biphasic effects of dopamine agonists on haloperiodol induced catalepsy
PC Dandiya1, Banerjee Pradeep2
1. At low doses, dopamine agonists, apomorphine (0.25-0.5 mg/kg), lisuride (0.001-0.01 mg/kg) and pergolide (0.005-0.01 mg/kg) lowered the latency period of haloperidol (0.25 mg/kg) induced catalepsy in rats. However, when higher doses were given, apomorphine (5.0-10.0 mg/kg) lisuride (0.05-0.1 mg/kg) and pergolide (0.25-1.0 mg/kg) increased the latency period.
2. Pretreatment with low doses of haloperidol(0.025-0.05mg/kg) partially prevented the lowering of the latency period due to low doses of dopamine agonists.
3. These findings tend to provide one more evidence to confirm that more than one group of dopamine receptors are involved in this typical biphasic response.
P C Dandiya
|How to cite this article:|
Dandiya P C, Pradeep B. Biphasic effects of dopamine agonists on haloperiodol induced catalepsy.Indian J Pharmacol 1986;18:9-13
|How to cite this URL:|
Dandiya P C, Pradeep B. Biphasic effects of dopamine agonists on haloperiodol induced catalepsy. Indian J Pharmacol [serial online] 1986 [cited 2023 Mar 22 ];18:9-13
Available from: https://www.ijp-online.com/article.asp?issn=0253-7613;year=1986;volume=18;issue=1;spage=9;epage=13;aulast=Dandiya;type=0