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Year : 1985  |  Volume : 17  |  Issue : 3  |  Page : 144--147

Serum and cerebrospinal fluid levels of phenytoin in epileptic patients in relation to control of seizures

NF Jaffery1, GK Ahuja2, BL Jailkhani3 
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2 
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Correspondence Address:
N F Jaffery


1. In 33 epileptic patients on phenytoin monotherapy. the CSF levels of the drug constituted 12.5( 5% (range 5.4 to 23%) of the serum levels. 2. The mean serum levels of the drug (13.356 (g/ml) in controlled patients (17) were not significantly different from the levels in uncontrolled patients (11). The mean CSF levels in uncontrolled patients (0.92(O.32) were significantly lower (p<0.001) than those in controlled patients (1.49(0.59). 3. In 5 patients who developed toxicity, the serum (27.3 ( 10.6) as well CSF (5.3 ( 1.8) levels of phenytoin were significantly higher than those of uncontrolled and controlled (without toxicity) patients.


How to cite this article:
Jaffery N F, Ahuja G K, Jailkhani B L. Serum and cerebrospinal fluid levels of phenytoin in epileptic patients in relation to control of seizures.Indian J Pharmacol 1985;17:144-147


How to cite this URL:
Jaffery N F, Ahuja G K, Jailkhani B L. Serum and cerebrospinal fluid levels of phenytoin in epileptic patients in relation to control of seizures. Indian J Pharmacol [serial online] 1985 [cited 2022 Aug 18 ];17:144-147
Available from: https://www.ijp-online.com/article.asp?issn=0253-7613;year=1985;volume=17;issue=3;spage=144;epage=147;aulast=Jaffery;type=0