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Year : 1985  |  Volume : 17  |  Issue : 2  |  Page : 108--112

Behavioural evidence for direct stimulation of rat brain 5-Hydroxytryptamine receptors by ergometrine

TR Bapat1, VP Gada2, NV Nandal3, JJ Balsara4, AG Chandorkar5 
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Correspondence Address:
T R Bapat


1. Ergometrine produced a behavioural syndrome in the rat which was characterized by head and body shakes, lateral head weaving, forepaw treading, hindlimb abduction and Straub tail. 2. Pretreatment with 5-HT receptor antagonists, cyproheptadine and methysergide, significantly decreased the intensity of the behavioural syndrome produced by ergometrine. 3. Pretreatment with p-chlorophenylalanine and clomipramine significantly decreased the intensity of the behavioural syndromes induced by fenfluramine and p-chloramphetamine but had no significant effect on the intensity of the behavioural syndrome produced by ergometrine. 4. The results indicate that ergometrine produces the 5-HT mediated behavioural syndrome by directly stimulating the central 5-HT receptors.


How to cite this article:
Bapat T R, Gada V P, Nandal N V, Balsara J J, Chandorkar A G. Behavioural evidence for direct stimulation of rat brain 5-Hydroxytryptamine receptors by ergometrine.Indian J Pharmacol 1985;17:108-112


How to cite this URL:
Bapat T R, Gada V P, Nandal N V, Balsara J J, Chandorkar A G. Behavioural evidence for direct stimulation of rat brain 5-Hydroxytryptamine receptors by ergometrine. Indian J Pharmacol [serial online] 1985 [cited 2021 Sep 17 ];17:108-112
Available from: https://www.ijp-online.com/article.asp?issn=0253-7613;year=1985;volume=17;issue=2;spage=108;epage=112;aulast=Bapat;type=0