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Year : 1985  |  Volume : 17  |  Issue : 1  |  Page : 70--72

Influence of anaesthesia on cardiotoxic effects of ouabain in guinea pigs

RM Tripathi1, GP Thomas2 
1 
2 

Correspondence Address:
R M Tripathi


(1) Cardiac arrhythmias were induced in guinea pigs anaesthetised with urethane and pentobarbitone sodium by slow intravenous infusion of ouabain. (2) The doses of ouabain required for the development of early arrhythmias, ventricular fibrillation and cardiac arrest in guinea pigs anaesthetised with urethane were significantly less compared to guinea pigs anaesthetised with pentobarbitone sodium. This may possibly be due to the inhibition of cardiovascular responses mediated via the inhibition of alpha, adrenoceptors by urethane.


How to cite this article:
Tripathi R M, Thomas G P. Influence of anaesthesia on cardiotoxic effects of ouabain in guinea pigs.Indian J Pharmacol 1985;17:70-72


How to cite this URL:
Tripathi R M, Thomas G P. Influence of anaesthesia on cardiotoxic effects of ouabain in guinea pigs. Indian J Pharmacol [serial online] 1985 [cited 2022 Jul 7 ];17:70-72
Available from: https://www.ijp-online.com/article.asp?issn=0253-7613;year=1985;volume=17;issue=1;spage=70;epage=72;aulast=Tripathi;type=0