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Year : 1984  |  Volume : 16  |  Issue : 2  |  Page : 112--114

Yohimbine prolongs the duration of antinociceptive activity of morphine in mice

AM Ageel1, OT Ginawi2 
1 
2 

Correspondence Address:
A M Ageel


1. The effect of intraperitoneal yohimbine on pain threshold in mice has been investigated. The drug was devoid of any analgesic activity at lower doses (1 mg/kg). However, the pain reactions was modified at 10 mg/kg. 2. Subanalgesic doses of yohimbine prolonged the duration of morphine analgesia. 3. Alteration in the ratio of brain 5 HT : Noradrenaline has been proposed as a possible mechanism for the effects of yohimbine.


How to cite this article:
Ageel A M, Ginawi O T. Yohimbine prolongs the duration of antinociceptive activity of morphine in mice.Indian J Pharmacol 1984;16:112-114


How to cite this URL:
Ageel A M, Ginawi O T. Yohimbine prolongs the duration of antinociceptive activity of morphine in mice. Indian J Pharmacol [serial online] 1984 [cited 2022 Aug 13 ];16:112-114
Available from: https://www.ijp-online.com/article.asp?issn=0253-7613;year=1984;volume=16;issue=2;spage=112;epage=114;aulast=Ageel;type=0