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| Year : 1984 | Volume
: 16
| Issue : 2 | Page : 112--114 |
Yohimbine prolongs the duration of antinociceptive activity of morphine in mice
AM Ageel1, OT Ginawi2
1
2
Correspondence Address:
A M Ageel
1. The effect of intraperitoneal yohimbine on pain threshold in mice has been investigated. The drug was devoid of any analgesic activity at lower doses (1 mg/kg). However, the pain reactions was modified at 10 mg/kg.
2. Subanalgesic doses of yohimbine prolonged the duration of morphine analgesia.
3. Alteration in the ratio of brain 5 HT : Noradrenaline has been proposed as a possible mechanism for the effects of yohimbine.
How to cite this article:
Ageel A M, Ginawi O T. Yohimbine prolongs the duration of antinociceptive activity of morphine in mice.Indian J Pharmacol 1984;16:112-114
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How to cite this URL:
Ageel A M, Ginawi O T. Yohimbine prolongs the duration of antinociceptive activity of morphine in mice. Indian J Pharmacol [serial online] 1984 [cited 2023 Jun 10 ];16:112-114
Available from: https://www.ijp-online.com/article.asp?issn=0253-7613;year=1984;volume=16;issue=2;spage=112;epage=114;aulast=Ageel;type=0 |
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