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Year : 1983  |  Volume : 15  |  Issue : 4  |  Page : 353--360

Involvement of histaminergic mechanisms in the antagonistic effect of morphine on methamphetamine stereotypy in mice

MP Muley1, JJ Balsara2, AG Chandorkar3 
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M P Muley


: Pretreatmentwith morphine was found to decrease the intensity of methamphetaminc stereotypy in mice.This inhibitory effect of morphine on methamphetamine stereotypy was significantly increased by prior treatment with L-histidine, a precursor of brain histamine, in a dose which per se had no significant effect on methamphetamine stereotypy. Further, pretreatment with chlorcyclizine, a H1 receptor antagonist, not only increased the intensity of methamphetamine stereotypy but also prevented morphine from exerting an inhibitory effect on methamphetamine stereotypy.The results with L-histidine and chlorcyclizine suggest an involvement of central histaminergic mechanisms in the inhibitory effect of morphine on methamphetamine stereotypy in mice.


How to cite this article:
Muley M P, Balsara J J, Chandorkar A G. Involvement of histaminergic mechanisms in the antagonistic effect of morphine on methamphetamine stereotypy in mice.Indian J Pharmacol 1983;15:353-360


How to cite this URL:
Muley M P, Balsara J J, Chandorkar A G. Involvement of histaminergic mechanisms in the antagonistic effect of morphine on methamphetamine stereotypy in mice. Indian J Pharmacol [serial online] 1983 [cited 2021 Nov 27 ];15:353-360
Available from: https://www.ijp-online.com/article.asp?issn=0253-7613;year=1983;volume=15;issue=4;spage=353;epage=360;aulast=Muley;type=0