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Year : 1983  |  Volume : 15  |  Issue : 4  |  Page : 349--351

Preliminary pharmacological studies on glycosides Symplocus spicata, roxb

YV Rao1, gupta G Das2, SB Acharya3, NKR Pathak4, M Biswas5 
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Y V Rao


A mixture of two chemically pure glycosides obtained from the stem bark of Symplocos spicata Roxb was studied for pharmacological actions. The glycosides (5 mg/kg, ip) possessed marked relaxant effect (equipotent with the relaxant effect of 10 g/kg, iv adrenaline) on intestine in situ and transient hypotension in anaesthetised dog and moderate relaxant effect on isolated rabbit ileum. The spasmogenic responses of DMPP and acetyl-choline were attenuated by 40% and 55% respectively on isolated guinea-pig ileum. The glycosides had positive inotropic and chronotropic actions on perfused frogSQs heart and a weak curare-like activity on isolated frogSQs rectus abdominis muscle. The glycosides did not have any CNS activity.


How to cite this article:
Rao Y V, Das gG, Acharya S B, Pathak N, Biswas M. Preliminary pharmacological studies on glycosides Symplocus spicata, roxb.Indian J Pharmacol 1983;15:349-351


How to cite this URL:
Rao Y V, Das gG, Acharya S B, Pathak N, Biswas M. Preliminary pharmacological studies on glycosides Symplocus spicata, roxb. Indian J Pharmacol [serial online] 1983 [cited 2021 Dec 8 ];15:349-351
Available from: https://www.ijp-online.com/article.asp?issn=0253-7613;year=1983;volume=15;issue=4;spage=349;epage=351;aulast=Rao;type=0