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Year : 1982  |  Volume : 14  |  Issue : 2  |  Page : 217--222

Effect of restraint stress on morphine antinociception in rats

SK Bhattacharya1, D Bhattacharya2 
1 
2 

Correspondence Address:
S K Bhattacharya


The effect of restraint stress (1, 2 and 4 h ) was investigated, in rats, on the antinociceptive action of a sub-analgesic dose (2.0 mg/kg, ip) of morphine. Restraint stress prduced a time-related potentiation of morphine antinociception. Stress (4 h)-induced potentiation of morphine analgesia was significantly attenuated after pretreatment with pharmacological agents known to decrease serotonergic and prostaglandin activity, but not by metyrapone, an inhibitor of endogenous corticoid synthesis. The results suggest that serotonin and prostaglandins are involved in restraint stress-morphine interaction.The results have been discussed in the context of earlier investigations, reported from this laboratory, indicating increase in rat brain serotonin and prostaglandin activity, following restraint stress. It has been suggested that restraint stress initially activates the proposed, first mediator, prostaglandins, which in turn modulates central serotonergic activity, to induce the observed potentiation of morphine analgesia by restraint stress.


How to cite this article:
Bhattacharya S K, Bhattacharya D. Effect of restraint stress on morphine antinociception in rats.Indian J Pharmacol 1982;14:217-222


How to cite this URL:
Bhattacharya S K, Bhattacharya D. Effect of restraint stress on morphine antinociception in rats. Indian J Pharmacol [serial online] 1982 [cited 2021 Sep 27 ];14:217-222
Available from: https://www.ijp-online.com/article.asp?issn=0253-7613;year=1982;volume=14;issue=2;spage=217;epage=222;aulast=Bhattacharya;type=0