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Year : 1981  |  Volume : 13  |  Issue : 2  |  Page : 207--210

Interaction of anti-inflammatory agents with glibenclamide in rabbit

VV Sharma1, YK Srivastava2, VK Kulshrestha3, DN Prasad4 
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Correspondence Address:
V V Sharma


The anti-inflammatory agents like. aspirin, phenylbutazone, indomethacin and ibuprofen were studied for drug interaction with glybenclamide in rabbits. All the agents studied excepting indomethacin interfered with glybenclamide induced hypoglycaemia. These drugs also affected carbohydrate metabolism per se as aspirin (40 mg/kg) produced hypoglycaemia and ibuprofen (10 mg/kg) hyperglycaemia. Pheaylbutazone (75 mg/kg) and aspirin (40 mg/kg) potentiated the glybenclamide induced hypoglycaemia.


How to cite this article:
Sharma V V, Srivastava Y K, Kulshrestha V K, Prasad D N. Interaction of anti-inflammatory agents with glibenclamide in rabbit.Indian J Pharmacol 1981;13:207-210


How to cite this URL:
Sharma V V, Srivastava Y K, Kulshrestha V K, Prasad D N. Interaction of anti-inflammatory agents with glibenclamide in rabbit. Indian J Pharmacol [serial online] 1981 [cited 2022 May 21 ];13:207-210
Available from: https://www.ijp-online.com/article.asp?issn=0253-7613;year=1981;volume=13;issue=2;spage=207;epage=210;aulast=Sharma;type=0