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| Year : 1981 | Volume
: 13
| Issue : 2 | Page : 185--194 |
Structure-activity relationship of benzopyrones towards their anti autacoid and anti-acetylcholine activity
DK Basu1, RSR Murty2, VVS Murty3
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Correspondence Address:
D K Basu
Six closely related classes ot benzopyrones have been screened for their anti-autacoid and antiacetylcholine activity on the guinea pig ileum preparation. Their effect on histamine release upon mast cell degranulaiton by compound 48/80 has also been evaluated. Chromones were found to be the most effective benzopyrones in antagonising brady-kinin, 5-HT and acetylcholine induced contractions of the guinea pig ileum as well as in inhibiting mast cell degranulation. None of the benzopyrone produced anti-histaminic activity on the ileum preparation. 2 methyl chromone substituted at position 7 and 8 by hydroxyl, alkoxyl or acetoxyl groups showed maximum activity in all the parameters studied.
How to cite this article:
Basu D K, Murty R, Murty V. Structure-activity relationship of benzopyrones towards their anti autacoid and anti-acetylcholine activity.Indian J Pharmacol 1981;13:185-194
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How to cite this URL:
Basu D K, Murty R, Murty V. Structure-activity relationship of benzopyrones towards their anti autacoid and anti-acetylcholine activity. Indian J Pharmacol [serial online] 1981 [cited 2023 Oct 1 ];13:185-194
Available from: https://www.ijp-online.com/article.asp?issn=0253-7613;year=1981;volume=13;issue=2;spage=185;epage=194;aulast=Basu;type=0 |
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